As you head south into the Delta on Highway 61, you can't miss the neon sign lighting up the Gateway to the Blues Visitors Center and Museum.
It's the perfect place to start your exploration of the Delta. Hands on exhibits place the region in historical context, try recording your own 12-bar blues song, and to pick up a map for the Mississippi Blues Highway. The Blues Trail starts right here; you'll dive deep into the history of American music from the first time you stop to read a blues marker.
The casino resort area is just West of the Visitor's Center on the banks of the mighty Mississippi River. There are eight casinos with all the dining options -- from steak houses to casual buffets, gaming, and the best in live entertainment.
The Tunica RiverPark and Museum is nearby and offers the best views of the Might Mississippi River with an introduction to the natural history of the region. The park has walking and biking trails if you'd like to get outside.
But don't just stay in the casino resort area. Head to Tunica Town, as locals call it, to visit the historic Blue and White Restaurant. It's right on Highway 61 and serves fresh donuts in the morning, fried green tomatoes later in the day.